Physician-Led · Peer-Reviewed · APOE ε4-Specific
APOE4 raises your risk.
It doesn’t decide your future.
Clear, practical guidance for APOE ε4 carriers and the people who love them — written by a neurologist who carries the ε4 allele himself, and based only on peer-reviewed research.
Brian Paquette, DO, MPH · Neurologist · APOE ε4 carrier · No ads · No industry funding
“I am building this platform to help those affected by Alzheimer’s dementia and to prevent or reverse the disease.”
Find your path
Where are you right now?
Choose the one that fits. We’ll show you the three pages to read first.
Early action matters. Start here.
Here’s what the evidence says helps.
You don’t have to figure this out alone.
Essential reading
Start with these three.
The questions carriers ask most, answered with the best available evidence.
Hope, grounded in data
Why Do Some APOE4 Carriers Never Develop Dementia?
What we know about carriers who stay cognitively healthy.
Read →What to do
Intervention Strategies: Ranking the Evidence
Which strategies have the strongest support — and which have failed.
Read →Two copies
I Have Two Copies of APOE4. Am I Going to Get Alzheimer’s?
An honest answer to the hardest question.
Read →Join
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Foundational articles, an overview of genotype-specific risk, basic lifestyle guidance, and the monthly newsletter.
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This website is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider regarding any medical condition or treatment decision.
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