Physician-Led · Peer-Reviewed · ApoE4-Specific
Your genome is not
your fate.
Act on the science.
1 in 4 people carry the APOE4 allele — the strongest known genetic risk factor for Alzheimer’s disease. The only platform built exclusively to translate cutting-edge genomic science into actionable, physician-curated guidance for carriers, clinicians, and families.
|
~25%
carry ≥1 ApoE4
allele globally |
3–4×
Alzheimer’s risk
ε3/ε4 carriers |
8–12×
Alzheimer’s risk
ε4/ε4 carriers |
100%
Physician-authored
content |
Who This Is For
Built for every stakeholder in the ApoE4 journey
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⚕️
Physicians & CliniciansEvidence-based frameworks for clinical care Peer-reviewed summaries, genotype-stratified risk protocols, and practical decision frameworks to elevate your care of ApoE4-positive patients. Clinical articles → |
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Patients & FamiliesUnderstand your risk. Build your plan. Clear, jargon-free explanations written by a physician who carries the gene himself — covering what ApoE4 means for your brain, your body, and your future. Start learning → |
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The Research-MindedSynthesis of the most impactful studies We track NEJM, Lancet Neurology, JAMA, Nature Medicine, and Cell Metabolism — and synthesize the findings that matter most for ApoE4 carriers. Browse research → |
Find your path
Where are you on this journey?
Select the description that fits you best.
We will point you to the resources most relevant to your situation.
You or a loved one has been diagnosed with mild cognitive impairment, mild dementia, or moderate dementia — and you want to understand what comes next.
You may carry the APOE ε4 gene — whether confirmed by testing or suspected from family history — and you have no symptoms yet. You’re here because early action matters.
You’re caring for someone living with cognitive decline — as a family member, friend, or healthcare provider — and you need clear, practical guidance.
APOE4 Insights Premium
Go Deeper. The Full Evidence Base,
For All Three Paths.
Premium membership unlocks complete clinical reviews, evidence tables graded by study type, dual-audience articles written for both patients and clinicians, and new peer-reviewed content published weekly — by a neurologist and pain medicine specialist who carries APOE ε4 himself.
Physician-led · Evidence-grounded · No ads · No industry funding
The Biology
ApoE4 raises risk. Risk is modifiable.
The APOE4 isoform impairs amyloid-β clearance via glymphatic and perivascular pathways, promotes tau hyperphosphorylation, disrupts synaptic lipid homeostasis, and accelerates neuroinflammation — mechanisms now illuminated by landmark trials including CLARITY AD, TRAILBLAZER-ALZ 2, and AHEAD 3-45.
Critically, ApoE4 penetrance is not deterministic. Large longitudinal cohort data confirm that modifiable lifestyle and metabolic variables — cardiovascular optimization, sleep architecture, dietary fat composition, insulin sensitivity, and cognitive reserve — substantively attenuate genotype-conferred risk.
Liu et al., Nat Rev Neurol (2013) · Raulin et al., Mol Neurodegeneration (2022) · Eisenberg et al., Cell Metab (2023) · van Dyck et al., NEJM (2023)
Lifetime Alzheimer’s Risk by APOE Genotype
| ε2/ε3 |
|
~9% |
| ε3/ε3 |
|
~15% |
| ε3/ε4 |
|
~30% |
| ε4/ε4 |
|
~50% |
Approximate cumulative risk to age 85.
Genin et al., J Alzheimers Dis (2011); Farrer et al., JAMA (1997); Corder et al., Science (1993).
What You Get
Rigorously sourced. Immediately applicable.
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01
Physician-authored exclusivelyWritten and reviewed by a board-certified neurologist with subspecialty training in pain medicine and a Master of Public Health — no ghostwriters, no wellness influencers. |
02
Peer-reviewed sources onlyWe cite NEJM, Lancet Neurology, JAMA, Nature Medicine, Cell Metabolism, and Alzheimer’s & Dementia. Never wellness blogs, podcasts, or social media. |
03
Genotype-stratified guidanceε3/ε4 and ε4/ε4 carriers face meaningfully different risk trajectories. We address the biology and strategy specific to each genotype. |
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04
Timely research synthesisThe field moves fast. Trial readouts, biomarker developments, and mechanistic findings are translated into practical language within days of publication. |
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Actionable lifestyle protocolsCardiovascular optimization, dietary fat composition, sleep architecture, insulin sensitivity, cognitive reserve — interventions with quantified effect sizes from the strongest available evidence. |
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Zero commercial biasNo pharmaceutical sponsorship. No supplement affiliates. No conflicts of interest. Guidance driven entirely by the evidence and the mission. |
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Physician-Scientist · ApoE4 Carrier Double Board Certified · |
About the Author “Knowledge of your genotype is not a sentence — it is a starting point.” As a neurologist and ApoE4 carrier with a deep family history of dementia, Dr. Brian Paquette has dedicated his practice to translating the most current peer-reviewed science into actionable, compassionate guidance. Training first as a US Naval Flight Surgeon instilled a discipline for high-stakes decision-making under uncertainty — a framework that translates directly to complex cognitive neurology. Brian Paquette, DO, MPH · Neurologist · Indianapolis, Indiana Read my full story → |
Member Voices
Trusted by patients. Respected by clinicians.
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★★★★★
“Finally — a resource I can hand to my ApoE4-positive patients without hesitation. The citations are impeccable and the clinical frameworks are immediately usable in practice.” Neurologist · Academic Medical Center · Member since 2024 |
★★★★★
“I found out I carry two copies of ApoE4 two years ago. This site transformed my understanding from fear into a concrete, evidence-based action plan. I come back every week.” Patient · ε4/ε4 carrier · Member since 2023 |
★★★★★
“The research summaries are extraordinary. This is the resource I desperately needed when my mother was diagnosed and I was trying to understand my own genetic results.” Caregiver & Healthcare Professional · Member since 2024 |
Membership
Knowledge is the most powerful intervention.
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Free Forever ExplorerNo cost, always
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Most Popular
Full Access PremiumFull access membership
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Clinicians Clinical ProFor licensed practitioners
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You don’t have to navigate this alone
The science exists. The guidance is here. The time is now.
Whether you’ve just received your genetic results or have spent years searching for reliable answers — this platform was built for you, by a physician who carries the same gene.
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ApoE4 Insights Physician-led, evidence-based guidance for people with one or two copies of the ApoE4 allele. Bridging the gap between genomic science and the patients, families, and clinicians navigating Alzheimer’s risk. |
Resources |
Site |
This website is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Content is intended to supplement, not replace, the physician-patient relationship. Always consult a qualified healthcare provider regarding any medical condition or treatment decision.
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